Dr Mark Petalcorin
Institute of Health Science, UBD

Charaterizing the  Antihypertensive and Antidyslipidemic Effects of Traditional Herbal Medicine on Animal Model Systems for Drug Herbal Research Discovery

  • The use of herbal medicine is becoming more popular with increasing reliance on natural products such as herbal plant remedies and formulations for treatment of diseases. 
  • This project is aimed at investigating the efficacy, stability, toxicity and mode of action of one of the four traditional herbal medicines (Gynura procumbens, Gymnema sylvestri, Goniothalamus velutinus or Pandanus amaryllifolius) and their bioactive components for medicinal use in potentially alleviating hypertension and dyslipidemia.
  • Insights into the molecular mechanism of how these herbs are able to lower the high blood pressure and modulate the lipid levels will contribute towards the design of new drugs with increased bioactivity for treatment against CVDs and cardio-metabolic disorders. 
  • Phenotype-based screen will be conducted to identify components with antihypertensive and antidyslipidemic potentials through in vivo pharmaco-genetic analysis of their effects on the lifespan, viability, behaviour, proliferation and lipid accumulation using two model organisms, rats and C. elegans, in conjunction with pharmacological in vitro assay involving vasodilation with isolated rat aorta. 
  • Fractionation of extracts by liquid chromatography, followed by evaluation of bioactivities of various components through phenotypic screens for toxicity, lipid levels modulation, cardio-metabolic alterations and health-status will identify druggable lead candidates. Insights into these candidates will provide the basis for future studies to identify further any novel drug target and the design of patentable synthetic and mimetic new molecules with better and more effective bioactivities for alleviating hypertension and dyslipidemia. 

Approved on 26 Sept 2018 – 2021

Total Grant = $38,500.00